UPDATE: Elderly man taken to hospital after crash near Deddington
The main road to Oxford was shut between Hopcrofts Lane in Deddington and the B4030 crossroads near North Aston due to the crash at around 9.45am.
South Central Ambulance Service sent two ambulances, a rapid response vehicle and the Thames Valley Air Ambulance to the incident.
One patient, an 86-year-old male, with serious injuries was treated at the scene before being taken by road to the major trauma centre at the John Radcliffe Hospital.
An Oxfordshire Fire and Rescue Service spokesman said firefighters attended the crash.
Thames Valley Police’s roads policing unit tweeted: “The A4260 between North Aston and Deddington is closed due to a serious collision.
“We hope to reopen in a few hours following investigation. Avoid the area due to delays. Thank you for your patience and understanding.”
Buses between Banbury and Oxford were unable to run because of the closure but the S4 service is back to normal.