Firefighters from the Chipping Norton, Hook Norton, Banbury and Kidlington fire stations were mobilised to a two car road traffic collision on the A361 just outside of Chipping Norton. The collision happened around 7.15pm on Wednesday September 15.
On arrival crews found three casualties, all medically trapped in the vehicles. Crews used hydraulic equipment to extricate the casualties from the vehicles.
The South Central Ambulance Service NHS Foundation Trust, Thames Valley Police and Thames Valley Air Ambulance all responded to the collision.
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Oxfordshire Fire and Rescue posted a public safety message on its Facebook after the collision, which said: "Watch Manager Dan Weeks would like to remind drivers just how important wearing a seatbelt can be in preventing serious injury.
"As the nights draw in and temperatures start to drop, always remember your lights and adjust your driving to suit the conditions."
A spokesperson for South Central Ambulance Service said: "We sent to the scene an ambulance officer, two ambulance crews, the critical care car and two air ambulance crews.
"They were assessing and treating three patients who were taken to hospital.
"One patient was assessed and treated at the scene and flown to University Hospital Southampton. Two patients following treatment at the scene for their injuries were taken to John Radcliffe Hospital."