Two brothers and a father and son team will be pounding the streets of London on April 24 to raise money for Agnes Court, the Leonard Cheshire home in Banbury.
Brothers Brett Purchase-Rathbone and Daryl Soper, together with son and father Michael and Chris Walker are in training for the London Marathon.
This will be the first marathon for the foursome.
Agnes Court was opened in 2008 by the Queen following a successful £1m fundraising appeal. It is a home with nursing care, providing services for adults with physical disabilities, accommodating 24 residents.
The home has assistive technology, which enables residents to open doors, control lighting and enjoy other facilities independently.
The most recent fundraising effort contributed £50,000 for a minibus to provide transportation for residents and now plans are being drawn up to extend the kitchen/diners at either side of the main building.
Successful fundraising to support these four runners in the marathon will go towards this project.