The clinic will stay open for approximately two weeks.
Opening times are to be confirmed, but on its first day it will operate for a half-day only but then move to full days.
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It will operate initially through booked appointments – and they can be booked through the NHS national booking system.
Leader of Banbury Town Council Kieron Mallon said: “We at the town council were concerned that our residents had to travel up to 20 miles for a booster jab.
“We offered our buildings and it seems the central location was what the health authorities wanted.
“The town hall is the perfect easy-to-get-to venue for a vaccination clinic. People who use the clinic should wear masks and be Covid aware at all times.”